ISSN 1662-4009 (online)

ey0018.6-15 | Longterm Effects of Hormonal Treatments in Gender Dysphoria | ESPEYB18

6.15. Development of Hip Bone Geometry During Gender-Affirming Hormone Therapy in Transgender Adolescents Resembles That of the Experienced Gender When Pubertal Suspension Is Started in Early Puberty

MA van der Loos , I Hellinga , MC Vlot , DT Klink , M den Heijer , CM Wiepjes

J Bone Miner Res. 2021 May;36(5):931–941. doi: 10.1002/jbmr.4262. PMID: 33507568.This restrospective study of the Cohort of Gender Dysphoria investigated bone geometry parameters of 106 adolescent trans-women and 216 adolescent trans-men during early and late start of gonadotropin-releasing hormone agonist (GnRHa) and gender affirming hormone therapy (GAHT). Transgender youth who started tr...

ey0019.6-12 | Gender Incongruence: Growth and fertility in transgender girls | ESPEYB19

6.12. Trans girls grow tall: adult height is unaffected by GnRH analogue and estradiol treatment

LS Boogers , CM Wiepjes , DT Klink , I Hellinga , Trotsenburg ASP van , Heijer M den , SE Hannema

J Clin Endocrinol Metab. 2022 Jun 6:dgac349. PMID: 35666195, doi: 10.1210/clinem/dgac349. Brief Summary: This paper reports the adult height of 161 transgender girls (registered male at birth) from the Amsterdam Cohort of Gender Dysphoria. It finds no difference in adult height between use of standard and high estrogen doses. There is currently very little information on...

ey0020.4-12 | Changes to Growth Patterns | ESPEYB20

4.12. Just as tall on testosterone; a neutral to positive effect on adult height of GnRHa and testosterone in trans boys

LA Willemsen , LS Boogers , CM Wiepjes , DT Klink , ASP van Trotsenburg , M den Heijer , SE Hannema

Brief summary: This paper investigated the effect of pubertal suppression with GnRHa and gender affirming treatment with testosterone on the growth and final height of transgender boys. They found no negative effects, and even possibly a slight boost to adult height in comparison with target and predicted heights for birth-registered sex.One of the concerning features of transgender males is being able to identify with their cisgender peers in stature. I...

ey0020.4-14 | Longer Term Outcomes | ESPEYB20

4.14. Continuation of gender affirming hormones in transgender people starting puberty suppression in adolescence: a cohort study in the Netherlands

MATC van der Loos , SE Hannema , DT Klink , M den Heijer , CM Wiepjes

Brief summary: Concerns exist that transgender adolescents opting for gender affirming treatments may subsequently regret their decision. This large study from Amsterdam provides information that in early adulthood, 98% of their cohort continued to access these treatments.The Amsterdam Cohort of Gender Dysphoria is one of the largest ongoing studies on the long-term outcomes of gender affirming hormone treatments (GAH). The authors presented outcomes at ...

ey0017.6-20 | Transgender Medicine: Treatment and Cardiovascular Effects | ESPEYB17

6.20. Hormonal treatment and cardiovascular risk profile in transgender adolescents

M Klaver , R de Mutsert , M van der Loos , CM Wiepjes , JWR Twisk , M den Heijer , J Rotteveel , DT Klink

To read the full abstract: Pediatrics. 2020, Mar; 145. doi: https://pediatrics.aappublications.org/content/pediatrics/145/3/e20190741.full.pdfCardiovascular health of transgender people was a hot topic in the transgender literature last year, triggered by previous findings that these individuals could have elevated risks for cardiovascular diseases b...

ey0020.4-10 | Gender Incongruence (GI): New Guidance | ESPEYB20

4.10. Standards of Care for the Health of Transgender and Gender Diverse People, Version 8

E Coleman , AE Radix , WP Bouman , GR Brown , ALC de Vries , MB Deutsch , R Ettner , L Fraser , M Goodman , J Green , AB Hancock , TW Johnson , DH Karasic , GA Knudson , SF Leibowitz , HFL Meyer-Bahlburg , SJ Monstrey , J Motmans , L Nahata , TO Nieder , SL Reisner , C Richards , LS Schechter , V Tangpricha , AC Tishelman , MAA Van Trotsenburg , S Winter , K Ducheny , NJ Adams , TM Adrian , LR Allen , D Azul , H Bagga , K Başar , DS Bathory , JJ Belinky , DR Berg , JU Berli , RO Bluebond-Langner , MB Bouman , ML Bowers , PJ Brassard , J Byrne , L Capitan , CJ Cargill , JM Carswell , SC Chang , G Chelvakumar , T Corneil , KB Dalke , G De Cuypere , E de Vries , M Den Heijer , AH Devor , C Dhejne , A D'Marco , EK Edmiston , L Edwards-Leeper , R Ehrbar , D Ehrensaft , J Eisfeld , E Elaut , L Erickson-Schroth , JL Feldman , AD Fisher , MM Garcia , L Gijs , SE Green , BP Hall , TLD Hardy , MS Irwig , LA Jacobs , AC Janssen , K Johnson , DT Klink , BPC Kreukels , LE Kuper , EJ Kvach , MA Malouf , R Massey , T Mazur , C McLachlan , SD Morrison , SW Mosser , PM Neira , U Nygren , JM Oates , J Obedin-Maliver , G Pagkalos , J Patton , N Phanuphak , K Rachlin , T Reed , GN Rider , J Ristori , S Robbins-Cherry , SA Roberts , KA Rodriguez-Wallberg , SM Rosenthal , K Sabir , JD Safer , AI Scheim , LJ Seal , TJ Sehoole , K Spencer , C St Amand , TD Steensma , JF Strang , GB Taylor , K Tilleman , GG T'Sjoen , LN Vala , NM Van Mello , JF Veale , JA Vencill , B Vincent , LM Wesp , MA West , J Arcelus

Brief summary: The World Professional Association for Transgender Health (WPATH) has issued an updated Standards of Care version 8 which contains important guidelines on how the assessment of gender variant children and adolescents should be considered, and by whom, and provides guidance around the consideration of young people for hormonal intervention.This long and detailed document has had considerable input from many experts involved in transgender c...